滋养细胞焦亡与子痫前期发病机制的研究进展·综述-国际妇产科学杂志.PDFVIP

20 17 12 44 6 J Int Obstet Gynecol December 20 17 Vol. 44 No. 6 610 国际妇产科学杂志 年 月第 卷第 期 ， ， ， · · ·综 述· 滋养细胞焦亡与子痫前期发病机制的研究进展 孙白云，乔东艳，于红△ 【摘 要 】 preeclampsia PE 子痫前期（ ， ）是妊娠期特有疾病，严重影响母胎结局。其发生机制并不十分明确，血管内 皮损伤及过度炎症反应是PE PE 的主要发病机制。研究发现，滋养细胞焦亡与 的发生关系密切，一方面使得滋养细胞 侵袭力下降、浸润过浅或受限，血管重铸异常，母胎界面缺血缺氧；另一方面，滋养细胞通过释放炎症因子，诱导免疫细 PE PE 胞聚集，炎性反应过度激活，血管内皮细胞损伤，进而导致 的发生。现对滋养细胞焦亡与 发病机制相关性的研究 进展进行综述。 【关键词 】 先兆子痫；滋养层；细胞死亡；炎症；焦亡 The Pyroptosis of Trophoblast in Relation to Preeclampsia SUN Bai -yun ，QIAO Dong -yan ，YU Hong. Medical College of Southeast University ，Nanj ing 210009 ，China （SUN Bai-yun ）；Dep artment of Gynecology and Obstetrics ，Zhongda Hosp ital Aff iliated to Southeast University ，Nanj ing 210009 ，China （QIAO Dong-yan ，YU Hong ） Corresp onding author ：YU Hong ，E-mail ：yuhong650325@ 【Abstract 】 Preeclampsia (PE) is the normal complication during pregnancy, Which seriously influences the maternal-fetal outcomes. The mechanisms are not clear. Vascular endothelial injury and over -reaction of inflammation are believed to be the main pathogenesis. It has been found that there is a close relationship between trophoblast pyroptosis and PE. On the one hand, pyroptosis reduces the invasion of trophoblast, which infiltrating too shallow or restricted, leading to abnormal blood vessels recasting, maternal-fetal interface ischemia and hypoxia. On the other hand, the release of inflammatory factors induces immune cells gathered, activates excessive inflammatory reactions, damages endothelial cell, leading to the occurrence of PE. In this paper,