硫酸软骨素Chondroitin sulphate reduces both cartilage volume.pdfVIP

Downloaded from on October 19, 2011 - Published by Extended report Chondroitin sulphate reduces both cartilage volume loss and bone marrow lesions in knee osteoarthritis patients starting as early as 6 months after initiation of therapy: a randomised, double-blind, placebo-controlled pilot study using MRI Lukas Martin Wildi,1 Jean-Pierre Raynauld,1 Johanne Martel-Pelletier,1 André Beaulieu,2 Louis Bessette,3 Frédéric Morin,4 François Abram,5 Marc Dorais,6 Jean-Pierre Pelletier1 ▶ Additional data ABSTRACT although recognised by the authorities, might not (supplementary text) are Objective To determine the effect of chondroitin sulphate have fully explored the drugs’ protective effect as published online only. To view (CS) treatment on cartilage volume loss, subchondral bone this technique allows for only an indirect assess- these articles please visit the journal online (http://ard.bmj. marrow lesions (BML), synovitis and disease symptoms in ment of the cartilage. Recent advances in MRI have com). patients with knee osteoarthritis (OA). enabled investigators to quantitatively and reliably ¹Osteoarthritis Research Unit, Methods In this pilot multicentre, randomised, double- assess cartilage thickness and volume, as well as University of Montreal Hospital blind, controlled trial in primary knee OA, 69 patients with the other joint structural changes occurring in the Research Centre (CRCHUM), clinical signs of synovitis were randomised to receive CS