硫酸软骨素氨基葡萄糖Effect of PreLoading Oral Glucosamine HCl.pdfVIP

EBM Experimental Biology and Medicine Effect of Pre-Loading Oral Glucosamine HCl/Chondroitin Sulfate/Manganese Ascorbate Combination on Experimental Arthritis in Rats Joel Beren, Susan L. Hill, Marie Diener-West and Noel R. Rose Experimental Biology and Medicine 2001, 226:144-151. Updated information and services can be found at: /content/226/2/144 © 2008 Society for Experimental Biology and Medicine Downloaded from / by guest on October 12, 2011 Effect of Pre-Loading Oral Glucosamine HCl/Chondroitin Sulfate/Manganese Ascorbate Combination on Experimental Arthritis in Rats ,1 ,1 , ,2 JOEL BEREN,* SUSAN L. HILL,† MARIE DIENER-WEST,† AND NOEL R. ROSE* † *Department of Pathology, †The W. Harry Feinstone Department of Molecular Microbiology and Immunology, and †Department of Biostatistics, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21205 The therapeutic effect of a nutritional supplement consisting of heumatoid arthritis (RA) is a significant health prob- a combination of glucosamine hydrochloride (FCHG49), puri- lem in terms of numbers of sufferers (U.S. incidence fied sodium chondroitin sulfate (TRH122), and manganese R23.7/100,000) and in degree of associated disability ascorbate (GCM)3 was investigated in the rat model of collagen- induced autoimmune arthritis (CIA). The GCM compound was as well (1). The disease is characterized by a chronic and mixed with a palatable nu