神经干细胞与脑梗死康复.pdfVIP

中国康复理论与实践 2007 年 12 月第 13 卷第 12 期 Chin J Rehabil Theory Pract , Dec . 2007 ,Vol . 13 , No . 12 ·1137 · ·综述 · 神经干细胞与脑梗死康复 1a 1a 1b 杨永轩 ,郭宗成 ,贾子善 ( ) [摘要] 近年来的研究证实 ,成年中枢神经系统内广泛分布着神经干细胞 N SC ,海马齿状回颗粒下层和侧脑室下区是成体 大脑内源性 N SC 存在的主要脑区。N SC 正常情况下处于静息状态 ,当大脑受到损伤或出现某些病理性变化时会被激活 ,分化为成 ( ) 熟的神经细胞 ,修复受损的神经功能 。可以通过某些手段 如康复训练 、丰富环境 、局部应用外源性神经生长因子 激活 自身干细胞 ( ) 或移植干细胞 包括 N SC 移植和非 N SC 移植 治疗脑梗死 。 [ 关键词] 神经干细胞 ;脑梗死 ;丰富环境 ;移植 ;综述 Neural Stem Cells and Ischemic Rehabilitation ( review) YA N G Yongx uan , GUO Zongcheng , J I A Z is han . The D ep a rtment of N eu rology , H ebei P rov i nci al Peop le’s H osp i t al , S hij i az h uang 050051 , H ebei , Chi na Abstract : Recent st udies have indicat ed t hat neural st em cell s (N SC) di st ribut e in t he adult cent ral nervou s syst em generally . Subgranular zone and subvent ricular zone are t he main di st rict s of t he endogenou s N SC in t he adult brain . These cell s drow se when t hey occup y normal condition , and are activat ed when t he brain i s inj uryed or comes to some p at hological change , and t hen differenti at e into mat ure nerve cell , recovery t he damaged nerves function . So t he i schemia can be t reat ed by activating endo genou s N SC or t ran sp lanting exo genou s st em cell s. The activating mean s include rehabilit ation t raining , enriched environment and utilizing exo ge nou