血流储备分数（FFR）在冠脉弥漫性病变介入治疗中的应用价值.docVIP

精品论文 参考文献 血流储备分数（FFR）在冠脉弥漫性病变介入治疗中的应用价值 张家港市第一人民医院 江苏张家港 215600 　　摘要：目的：探讨血流储备分数（FFR）指导冠心病患者冠状动脉弥漫性病变治疗策略的应用价值。方法：选择51位冠脉造影（CAG）提示冠状动脉弥漫病变患者，对照组35例，常规行PCI术植入药物涂层支架（DES），实验组16例均行FFR检测，指导支架植入策略。所有病人均行最优化药物治疗。临床终点是一年后主要心脏不良事件发生率（MACE），定义为死亡、心肌梗死、血运重建在内的复合事件。次级终点包括住院时间，支架使用数量以及住院费用等。结果：FFR组和常规治疗相比，平均支架植入分别为0.1205plusmn;0.3416枚和1.9714plusmn;0.5137枚，平均住院费用分别为41341.75plusmn;19445.26元和78680.2plusmn;26352.46元，住院时间分别为11.8125plusmn;3.08天和11.8857plusmn;5.94天，因心血管事件再入院率分别为11.25%和8.75%。FFR组在支架植入的数量及住院的费用较对照组明显降低，但两组患者在住院时间及随访1年间的MACE发生的差异无明显统计学意义。结论：1、冠脉血流储备分数（FFR）引导的PCI术是冠状动脉弥漫病变介入治疗中的一个安全、可靠、有效的策略。2、冠脉造影并不能全部真正反映心肌缺血情况。3、通过FFR指导PCI治疗冠脉弥漫性病变较常规PCI治疗对中期预后没有影响。 　　关键词：冠心病；冠脉血流储备分数；弥漫病变；经皮冠状动脉介入治疗 　　The value of Fractional Flow Reserve-Guided Percutaneous coronary Intervention in Patients With diffused coronary lesions 　　Abstract 　　Objective：This study is to make into the value of fractional flow reserve-guided percutaneous coronary intervention in patients with diffused coronary lesions. 　　Methods：Assigned 51 patients with diffused coronary lesions to undergo PCI with implantation of drug—eluting stents guided by angiography alone（conventional group）or guided by FFR measurements in addition to angiography（FFR group）.Lesions requiring PCI were identified on the basis of their angiographic appearance。The primary end point was the rate of death，nonfatal myocardial infarction and repeat 　　revascularization at 1 year．The second end point was the number of implanted stents，the Economic Evaluation and time of hospitalization。 　　Results：Compared with Conventional group，The number of stents used per patient was 0.1205plusmn;0.3416 and 1.9714plusmn;0.5137，The average hospital costsrespectivel was 41341.75plusmn;19445.26 yuan and 78680.2plusmn;26352.46 yuan，The average hospital stay was 11.8125plusmn;3.08 days and 11.8857plusmn;5.94 days，readmission rates was 11.25% and 8.75%.FFR group have lower numbers of stents and hospital costs，but there is no difference in Hospital stay and the inci