中国传统抗衰老药物黄精的研究进展李春生1侯荣先21.DOCVIP

中國傳統抗衰老藥物黃精的研究進展 李春生1 侯榮先2 （1.香港東華三院東華東院中醫中心工作、中國中醫科學院西苑醫院主任醫師 2.北京：中國中醫科學院西苑醫院圖書館副研究館員。） 【摘要】目的：考察抗衰老中藥黃精近10年的化學、藥理和臨床的研究現狀。方法：收集1998—2007年間國內外發表的有關黃精及其提取物研究的論文和報道，加以綜述。結果：黃精中新發現成分為木質素、特有蛋白質及5種多糖。對其延緩衰老、免疫增強、抗動脈硬化、調節血糖、提高生命活力、抗病毒的研究有所深化，發現本品有較好的抗皮膚衰老、改善記憶、保護腦細胞、抗乾眼病、抗結核作用。結論：黃精是一種保健和治療功效兼備的傳統延緩衰老中藥。 【關鍵詞】黃精 化學 藥理學 衰老/藥物作用 綜述 The Progress of the Study of Traditional anti-aging Chinese drug Polygonatum sibiricum Delar.ex Redonte 　　 【ABSTRACT】 Objective To investigate the progress of the chemical, pharmacodynamics and clinical study of the anti-aging drug Polygonatum sibiricum Delar.ex Redonte in the recent ten years. Methods Collect and summarize the journals and reports related to the study of Polygonatum sibiricum Delar.ex Redonte and it掇 extracts in Mainland China and foreign countries from 1998 to 2007. Results The new components found in Polygonatum sibiricum Delar.ex Redonte include lignin, special proteins and five kinds of polysaccharides. There are more in-depth researches on the functions of postpone the aging process, to enhance immunity, prevent arteriosclerosis, to regulate blood sugar level, to raise the vitality, and also anti-virus about Polygonatum sibiricum Delar.ex Redonte, It is found that Polygonatum sibiricum Delar.ex Redonte is good for anti-aging of skin, improve the faculty of memory, protect brain cell, anti-xerophthalmia and anti-tuberculosis. Conclusion Polygonatum sibiricum Delar.ex Redonte is a traditional anti-aging Chinese drug which has both health care and treatment function. 【KEY WORDS】 Polygonatum sibiricum Delar.ex Redonte; Chemistry; Pharmacology; Decrepit/Drug effects ; Summary 黃精（Polygonatum sibiricum Delar.ex Redonte）是百合科植物黃精、多花黃精和滇黃精的根莖，屬於補益類傳統延緩衰老藥物。本品味甘性平無毒，歸肺脾腎三經，功能滋陰潤肺、補脾益氣、滋腎填精，長於治療勞嗽、消渴、少食口乾、陽痿遺精、耳聾目暗、鬚髮早白、體虛羸瘦，風癩癬疾等病証。《名醫別錄》謂其「主補中益氣，除風濕，安五臟，久服輕身延年」。新中國成立以來，對黃精做了大量研究，發現本品含有多種甾體皂、黃精多糖、洋地黃糖以及少量蔥類化合物等。藥理研究證實，本品具有延長家蠶生存期、對抗自由基損傷、增強免疫功能，調節第二信使環磷酸腺（cAMP）水平、增強心肌收縮力、增強冠狀動脈血流量、降血糖、降血脂、抗菌、抗病毒、抗幅射、抗突變、抗疲勞等作用。是一種有很好開發前景