术前地塞米松对结直肠癌术后全身炎症反应及并发症的影响.docxVIP

术前地塞米松对结直肠癌术后全身炎症反应及并发症的影响【摘要】目的：探究术前使用塞米松对结直肠癌术后全身炎症反应及并发症的影响。方法：随机选取我院2014年6月-2016年6月收治的行结直肠癌手术的患者90例，将他们分为研究组和对照组，每组各45例。给予对照组患者常规静脉麻醉，研究组患者在此基础上联合地塞米松辅助麻醉。对比两组患者手术治疗前后VAS评分、炎症反应相关指标、胃功能恢复情况、并发症的发生率。结果：手术前两组患者的VAS评分无明显区别（P＞0.05），手术后两组患者的VAS评分均有明显改善，研究者患者改善程度显著高于对照组（P＜0.05）；手术前两组患者的C反应蛋白（CRP）、白细胞计数（WBC）、淋巴细胞比例（N%）等炎症指标无明显区别（P＞0.05），手术后两组CRP、WBC、N%均低于手术前，且研究组患者明显低于对照组（P＜0.05）；手术后两组患者肛门排气时间、平均住院时间均显著短于对照组（P＜0.05），同时研究组术后恶心呕吐评分显著低于对照组患者（P＜0.05）。研究组患者相关并发症的发生概率均低于对照组患者（P＜0.05）。结论：术前应用地塞米松辅助治疗行结直肠癌手术患者效果显著，能够明显减轻患者痛苦，有效缩短住院时间，可在临床上大力推广使用。【关键词】地塞米松；直肠癌手术；全身麻醉；并发症Clinical effect of Dexamethasone in the inflammatory response and complications after the operation of colorectal cancer [Abstract] Objective: To explore the clinical effect of Dexamethasone in the inflammatory response and complications after the operation of colorectal cancer. Method:90 patients of receiving the operation of colorectal cancer from June 2014 to June 2016 in our hospital were selected. The subjects were divided into two groups, 45 cases each group. Before surgery, the control group took the conventional intravenous anesthesia; on the basis, the study group also took the assisted anesthesia of Dexamethasone. The VAS points, inflammatory indicators,gastric function recovery and incidence rate of complications for two groups were compared.Result:Before surgery, the VAS points for two groups were not significantly different (P＞0.05); after surgery, the VAS points for study group were even better than control group (P＜0.05);before surgery, the inflammatory indicators of CRP, WBC and N% for two groups were not significantly different (P＞0.05);after surgery, the index of CRP, WBC and N% for study group were even lower than control group (P＜0.05);after surgery, the anal exhaust time and average hospitalization time for study group were significantly shorter than control group (P＜0.05);the evaluation scores of postoperative nausea and vomiting for study group were lower than control group (P＜0.05);the i