临床药物手册( 英文原版)15.pdfVIP

Drug Interactions and Interferences 5 Cytochrome P450 Enzyme Interactions Philip D. Hansten Cytochrome P450 enzymes are found throughout the body and play an important role in the metabolism of many drugs by catalyzing -hydroxylation, N- demethylation, ring oxidation, and more.1,2 Most substrates are metabolized by a specific enzyme, whereas each cytochrome P450 enzyme is generally capable of metabolizing