mta1、ki―67在非小细胞肺癌中的表达及相关性分析.docVIP

MTA1、Ki―67在非小细胞肺癌中的表达及相关性分析 　　[摘要]目的 初步探讨非小细胞肺癌（NSCLC）组织中转移相关蛋白1（MTA1）和增殖细胞核抗原（Ki-67）的表达并分析其相关性。方法 采用SP免疫组织化学方法检测2011年1月～2017年1月内蒙古林业总医院经胸外科手术切除并经病理科存档，符合实验条件的46例NSCLC组织和20例癌旁正常对照组织中MTA1和Ki-67的表达，分析MTA1和Ki-67之间的相关性及其与NSCLC临床病理参数的关系。结果 NSCLC组织中MTA1和Ki-67的阳性率分别为65.22%和54.35%，均显著高于癌旁对照组织中的15%和20%（P0.05）；NSCLC发生淋巴结转移组MTA1表达的阳性率高于无淋巴结转移组（P 　　[关键词]MTA1；Ki-67；非小细胞肺癌 　　[中图分类号] R735.1 [文献标识码] A [文章编号] 1674-4721（2017）04（b）-0084-03 　　Expression and correlation of MTA1 and Ki-67 in non small cell lung cancer 　　LI Hao1 YAN Cong-ying2 HOU Dian-chen3▲ 　　1.Clinical Medical School of Inner Mongolia University for Nationalities，Tongliao 028000，China；2.Department of Cardiology，the First Hospital of Hebei Medical University，Shijiazhuang 050000，China；3.Department of Thoracic Surgery，the Second Clinical Medical School of Inner Mongolia University for Nationalities （Inner Mongolia Forestry General Hospital），Yakeshi 022150，China 　　[Abstract]Objective To investigate the expressions of metastasis associated protein 1 （MTA1） and proliferating cell nuclear antigen （Ki-67） in non-small cell lung cancer （NSCLC） tissues and their correlation.Methods 46 cases of NSCLC tissues and 20 cases of normal tissues in Inner Mongolia Forestry General Hospital from January 2011 to January 2017 were selected as the research objects，immunohistochemistry of SP was used to detect the expressions of MTA1 and Ki-67 in NSCLC tissues and adjacent paracancerous tissues.The correlation between their expression and pathologic parameters were analyzed by statistics.Results The positive expressions rate of MTA1 and Ki-67 in NSCLC tissues were 65.22% and 54.35%，significantly higher than the positive expressions rate of 15% and 20% in normal tissues （P0.05）；the positive expression rate of MTA1 in the group of lymph node metastasis of NSCLC was higher than that without lymph node metastasis （P 　　1对象与方法 　　1.1对象 　　选取内蒙古林业总医院2011年1月～2017年1月经胸外科手术切除并经病理科存档的符合实验条件的NSCLC癌组织46例，配对切取并筛选出符合实验条件的距肿瘤边缘?5 cm的癌旁肺组织作为对照20例，所有患者