Trends in lipasecatalyzed 2007 大学有机化学教学资料.pdf

Tetrahedron 63 (2007) 1721–1754 Tetrahedron report number 786 Trends in lipase-catalyzed asymmetric access to enantiomerically pure/enriched compounds Ashraf Ghanem* Biomedicinal Chemistry Unit, Biological and Medical Research Department (MBC-03-95), King Faisal Specialist Hospital and Research Centre, PO Box 3354, Riyadh 11211, Saudi Arabia Received 26 September 2006 Available online 1 November 2006 Abstract—Over the last few years, there has been a dramatic increase in the number of publications in the field of lipase-catalyzed reactions performed in common organic solvents, ionic liquids or even non-conventional solvents. A fairly large percentage of these publications have emerged from organic chemists who have recognized the potential of biocatalysis as a viable and popular technique in organic synthesis. Considerable research has shown that reactions catalyzed by enzymes are more selective and efficiently performed than many of their ana- logues in the organic chemistry laboratory. This review article focuses on some of the recent developments in the rapidly growing field of lipase-catalyzed asymmetric access to enantiomerically pure/enriched compounds. The literature search is dated back to the last five years and covers some comprehensive examples. 2006 Elsevier Ltd. All rights reserved. Contents 1. Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .