靶向抑制交感神经活性对自发性高血压大鼠血压的影响.docVIP

精品论文 参考文献 靶向抑制交感神经活性对自发性高血压大鼠血压的影响 方胜先1 彭文君1 洪雷1 钟庆华1 许瑞环1 朱正1 朱平先2(通讯作者) 　　(1 深圳市龙岗中心医院 广东深圳 518116) 　　(2 深圳市龙岗区人民医院 广东深圳 518116 ) 　　【摘要】目的 探讨使用放射性同位素标记的间碘卞胍(131I-MIBG)对自发性高血压大鼠(SHR)血压的影响。 方法 将24只SHR随机分为对照组和干预组，干预组按预试验结果腹腔注射(ip)131I-MIBG，连续监测注射131I-MIBG后血压及脉搏改变，并在血压变化有统计学意义时测血清去甲肾上腺素(NE)及肾上腺素(E)水平。结果 注射131I-MIBG后干预组SHR第2天时血压下降有统计学差异，此后测血清NE、E水平亦明显低于对照组(P分别＜0.01和0.05)，第8天SHR血压逐渐回升，与对照组对比无统计学意义(P＞0.05)，此后检测血清NE、E水平相应上升,并与对照组无明显差异(P＞0.05)，脉搏也相应改变。结论 131I-MIBG对SHR血压具有一定的降低作用，并可维持数天，其机制可能与131I-MIBG损坏肾上腺能组织、降低儿茶酚胺水平有关。 　　【关键词】131碘间碘卞胍 自发性高血压大鼠 血压 去甲肾上腺素 肾上腺素 　　【中图分类号】R965 【文献标识码】A 【文章编号】2095-1752（2014）24-0028-03 　　Effects of Target Suppressing the Activity of Sympathetic Nerve on Blood Pressure in Spontaneous Hypertensive Rats 　　1. FANG Sheng-xian, PENG Wen-jun, HONG Lei, XU ruihuang, ZHU zhen;2.ZHU pingxian 　　(1. Longgang Central Hospital of Shenzhen, Shenzhen 518116,China; 2.Longgang Hospital of Shenzhen, Shenzhen 518172, China;) 　　【Abstract】To observe the effects of 131I-metaiodobenzylguanidine (131I-MIBG) on the blood pressure in spontaneous hypertensive rats (SHR). Methods 24 SHRs were randomly divided into control group and intervention group, the blood pressure and pulse were monitored every day after ip 131I-MIBG according to the pre-experiment results, and the levels of serum norepinephrine (NE) and epinephrine (E) were detected when blood pressure changed significantly. Results After ip 131I-MIBG, blood pressure decreased significantly in 2th day, and the levels of NE and E also were lower in intervention group than control group (P＜0.01 and 0.05 respectively) afterwards, all indicators were observed recovery in intervention group, and no significant difference between two groups in 8th day. Conclusions131I-MIBG can decrease SHR blood pressure and maintain for several days, which may be relate to the damage of adrenergic tissue and decrease NE and E levels by 131I-MIBG. 　　【Key words】]131I-metai