香烟对慢阻肺患者气道平滑肌的影响.pdfVIP

ORIGINAL ARTICLE COPD AND SMOKING Effects of cigarette smoke extract on human airway smooth muscle cells in COPD 1,2 2,3 2,4 5 1,6 Ling Chen , Qi Ge , Gavin Tjin , Hatem Alkhouri , Linghong Deng , 7 8 7 9 Corry-Anke Brandsma , Ian Adcock , Wim Timens , Dirkje Postma , Janette K. Burgess2,3,4, Judith L. Black2,3 and Brian G.G. Oliver2,10 Affiliations: 1Key Laboratory of Biorheological Science and Technology, Ministry of Education, Bioengineering College, Chongqing University, Shapingba, Chongqing, China. 2Woolcock Institute of Medical Research, The University of Sydney, Sydney, NSW, Australia. 3 Discipline of Pharmacology, The University of Sydney, Sydney, NSW, Australia. 4Central Clinical School, The University of Sydney, Sydney, NSW, Australia. 5 Respiratory Research Group, Faculty of Pharmacy, The University of Sydney, Sydney, NSW, Australia. 6 Institute of Biomedical Engineering and Health Science, Changzhou University, Changzhou, Jiangsu, China. 7Dept of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. 8Thoracic Medicine, Imperial College London, National Heart and Lung Institute, London, UK. 9 Dept of Pulmonology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. 10School of Medical and Molecular Biosciences, University of Technology Sydney, Sydney, NSW, Australia. Correspondence: Brian G.G. Oliver, School of Medical and Molecular Biosciences, University of Technology Sydney, City campus, 15 Broadway, Ultimo NSW 2007, Australia. E-mail: brian.oliver@.au ABSTRACT We hypothesised that the