Multi-objective dynamic population shuffled frog-leaping biclustering of microarray data精选.pdfVIP

Liu et al. BMC Genomics 2012, 13(Suppl 3):S6 /1471-2164/13/S3/S6 PROCEEDINGS Open Access Multi-objective dynamic population shuffled frog- leaping biclustering of microarray data 1 2,3 4,5* 6 7 Junwan Liu , Zhoujun Li , Xiaohua Hu , Yiming Chen , Feifei Liu From IEEE International Conference on Bioinformatics and Biomedicine 2011 Atlanta, GA, USA. 12-15 November 2011 Abstract Background: Multi-objective optimization (MOO) involves optimization problems with multiple objectives. Generally, theose objectives is used to estimate very different aspects of the solutions, and these aspects are often in conflict with each other. MOO first gets a Pareto set, and then looks for both commonality and systematic variations across the set. For the large-scale data sets, heuristic search algorithms such as EA combined with MOO techniques are ideal. Newly DNA microarray technology may study the transcriptional response of a complete genome to different experimental conditions and yield a lot of large-scale datasets. Biclustering technique can simultaneously cluster rows and columns of a dataset, and hlep to extract more accurate information from those datasets. Biclustering need optimize several conflicting objectives, and can be solved with MOO methods. As a heuristics-based optimization approach, the particle swarm optimization (PSO) simulate the movements of a bird flock finding food. The shuffled frog-leaping algorithm (SFL) is a population-based cooperative search metaphor combining the benefits of the local search of PSO and the global shuffled of information of the complex evolution technique. SFL is used to solve the optimization problems of the large-scale datasets. Results: This paper integrates dynamic population strategy and shuf