Bacterial virulence factors targeting Rho GTPases parasitism英文资料.pdfVIP

238 Review TRENDS in Cell Biology Vol.13 No.5 May 2003 Bacterial virulence factors targeting Rho GTPases: parasitism or symbiosis? Patrice Boquet and Emmanuel Lemichez INSERM U452, IFR50, Faculty of Medicine 28 Avenue de Valombrose, 06107 Nice, France In the past few years, an important question in micro- biology has arisen from reports indicating that several pathogenic bacteria have evolved virulence factors Inflammation and cell death activation/deactivation induced by bacteria directed towards a Ras subfamily of GTPases, namely Transcriptional control of apoptosis modulators and inflammatory mediators the Rho GTPases. Progress made in studying both the Nucleus SRF NF-κB c-Jun virulence factors and the signaling pathways involving Cytosol NF-κB JNK Rho GTPases has shed light on this crosstalk. One central IκB Proteasome MKK 4, 7 question is raised by the findings that both activating MLK1, 2, 4 IKK and inactivating virulence factors that target Rho PAK GTPases coexist in some pathogenic bacteria. Further Rho ? Rac Cdc42 studies on this peculiar aspect of the bacteria–host cell Oxidase O– interactions, which leads to the outbrea