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Research Article
Peroxisome Proliferator-Activated Receptor ; Inhibition Prevents
Adhesion to the Extracellular Matrix and Induces Anoikis in
Hepatocellular Carcinoma Cells
1 1,3 4 5
Katherine L. Schaefer, Koichiro Wada, Hirokazu Takahashi, Nobuyuki Matsuhashi,
5 1 6 4 2
Shin Ohnishi, M. Michael Wolfe, Jerrold R. Turner, Atsushi Nakajima, Steven C. Borkan,
1
and Lawrence J. Saubermann
Sections of 1Gastroenterology and 2Nephrology, Boston Medical Center, Boston, Massachusetts; 3Department of Pharmacology, Osaka
University, Osaka, Japan; 4Division of Gastroenterology, Yokohama City University School of Medicine, Yokohama, Japan; 5Department of
Medicine, University of Tokyo, Tokyo, Japan; and 6Department of Pathology, University of Chicago, Chicago, Illinois
Abstract stimulation might favor cancer remission, clinical trials with
Activation of the nuclear transcription factor peroxisome thiazolidenediones have currently shown modest to little efficacy
proliferator-activated receptor ; (PPAR;) inhibits growth and (6, 10, 11).
survival of hepatocellular carcinoma (HCC) cell lines. To Whereas PPARg activation is associated with tumor cell death in
further investigate the function of PPAR; in HCC, PPAR; some cases, several observations suggest that the i
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