高血压合并冠心病患者血浆叶酸和同型半胱氨酸水平变化.docVIP

精品论文 参考文献 高血压合并冠心病患者血浆叶酸和同型半胱氨酸水平变化 陈玲 吕湛 　　（川北医学院附属医院心内科 四川 南充 637000） 　　【摘要】 目的：观察单纯高血压与高血压合并冠心病患者血浆中叶酸及同型半胱氨酸变化。方法：纳入我院2013～2014年收治入院的高血压合并冠心病组65例、单纯高血压患者75例与正常对照组60例对比。应用循环酶法测定同型半胱氨酸水平，化学发光法检测叶酸水平，比较单纯高血压病与高血压病合并冠心病患者血浆中叶酸及同型半胱氨酸水平。结果：高血压合并冠心病组及 单纯高血压组同型半胱氨酸均高于正常对照组，叶酸水平均低于正常对照组，其差异性具有统计学意义；高血压合并冠心病组及与单纯高血压组对比，同型半胱氨酸及叶酸水平无明显差异。结论：检测血清同型半胱氨酸及叶酸水平对高血压、冠心病的诊断及治疗均具有重要的临床意义，对疾病 研究也具有重要意义。 　　【关键词】 高血压；冠心病；同型半胱氨酸；叶酸 　　【中图分类号】R544.1 【文献标识码】A 【文章编号】2095-1752（2016）10-0118-02 　　The changes of serum folic acid and homocysteine levels in patients with hypertension and coronary heart disease 　　【Abstract】Objective To observe the changes of folic acid and homocysteine in patients with hypertension and hypertension complicated with coronary heart disease, Methods 65 cases of hypertension combined with coronary heart disease, 75 cases of simple hypertension patients and 60 cases of normal control group in our hospital since 2013 to 2014 were included in this study. The level of homocysteine was determined by cyclic enzymatic method, and the level of folic acid was detected by chemiluminescence immunoassay,to comp-are the levels of folic acid and homocysteine in plasma of patients with hypertension and hypertension complicated with coronary heart disease. Results The levels of homocysteine in hypertension compl-icated with coronary heart disease and hypertension were higher than those in control group, and the differences were statistically si-gnificant; There was no significant difference of the level of hom-ocysteine and folic acid between the patients with hypertension com-plicated with coronary heart disease and those with hypertension. Conclusions It is great significance to the diagnosis and treatment of hypertension and coronary heart disease by the detection of the serum homocysteine and folic acid levels. 　　【Key words】 Hypertension; coronary heart disease; homocysteine; folic acid 　　高血压病和冠心病是目前全球发病率高，严重危险人类健康的主要疾病。高血压病伴有同型半胱氨