２型糖尿病合并高血压患者血浆同型半胱氨酸与颈动脉内中膜厚度的关系.docVIP

精品论文 参考文献 ２型糖尿病合并高血压患者血浆同型半胱氨酸与颈动脉内中膜厚度的关系 刘起琛１　刘长山２　刘素华１　刘晓娜１　梁磊３　李慧明３　柳林 ２通信作者山东潍坊滨海经济技术开发区人民医院１内分泌科３超声科　山东　２６２７３７;２潍坊市人民医院内分泌科　山东　潍坊　２６１０４１ 　　【摘要】　　目的　探讨２型糖尿病(T２DM)合并高血压患者血浆同型半胱氨酸(Hcy)与颈动脉内膜－中层厚度(IMT)的关系.方法　回顾性分析在我院住院的１８０例T２DM 患者临床资料,按伴有高血压与否,分为单纯糖尿病组(DM 组)８６例、高血压合并T２DM 组(HBP＋DM 组)９４例,单纯高血压病组(HBP 组)８３例,另选择健康体检者８５例为健康对照组.均测定HbA１c、TC、TG、HDL、LDL、FBG 等指标及血Hcy,彩色多普勒超声仪行颈动脉内膜中层厚度检查, 进行比较分析.结果　DM 组、HBP组、HBP＋DM 组血浆Hcy水平明显高于正常对照组(P＜０．０１).HBP＋DM 组血浆Hcy水平均高于HBP组及DM 组(P＜０．０１).HBP＋DM 组IMT均高于DM 组、HBP组及对照组(P＜０．０１).结论　T２DM 合并高血压患者血Hcy水平与颈动脉内膜－中层厚度程度密切相关. 【关键词】　糖尿病,２型;高血压;同型半胱氨酸;颈动脉内中膜厚度; Relationshipbetweentheplasmlevelofhomocysteineandcaroticintmial－medialthicknessintype２diabetescomplicatedwithhypertension　LiuQichen,LiuChangsＧhan,LiuSuhua,LiuXiaona,LiangLei,LiHuiming,LiuLin．BinhaiEconomicdevelopmentzonepeoplersquo;shospital,Weifang ,Shandong,２６２７３７．　CorreＧspondingauthor:LiuLin　Email:liulin_sd＠sina．com【Abstract】Objective　Todiscusstherelationshipbetweentheplasmlevelofhomocysteine(Hcy)andcaroticintmial－medialthickness(IMT)intype２diaＧbetes(T２DM)complicatedwithhypertension．Methods　Aretrospectiveanalysisoftheclinicaldataof１８０casesofpatientswithT２DMinourhospital,accordＧingtowhetherornocomplicatedhypertension,patientsweredividedintoDMgroup(DM)８６cases,hypertensioncomplicatedwithT２DM (HBP＋DMgroup)９４cases．８５ageandsex－matchedhealthysubjectsselectedascontrolgroupandselecthypertensiongroup(HBPgroup)８３cases．DetectedtheHbA１c,TC,TG,HDL,LDL,FBGandplasmaHcyoffourgroups．Inspectedcarotidintima－mediathicknessbyColorDopplerultrasoundandanalyzedtheresults．Results　Comparedthecontrolgroup,plasmaHcylevelsweresignificantlyhigherinDMgroup,HBPgroupandHBP＋DMgroup(P＜０．０１);thelevelsofplasmaHcyofHBP＋DMgroupwerehigherthanthatofHBPandDMgroup(P＜０．０１),theIMTofHBP＋DMgroupwerehigherthanDMgroup,HBPgroupandcontrolgroup(P＜０．０１)．Conclusion　Theplasmalevelofhomocysteine wascloselyrelatedtocaroticintmial－ medialthicknessin T２DM complicated withhyper【tKeenysiownor　ds】diabetesmellitus,type２;hypertension;homocysteine;carotic