吴茱萸中1个新的苯丙素苷类化合物.pdf

中草药 Chinese Traditional and Herbal Drugs 第 46 卷 第 1 期 2015 年 1 月 ·15 · 吴茱萸中 1 个新的苯丙素苷类化合物 * 赵 楠，李占林，李达，华会明 沈阳药科大学 基于靶点的药物设计与研究教育部重点实验室，辽宁 沈阳 110016 摘 要：目的 研究吴茱萸 Euodia rutaecarpa 的化学成分。方法 采用硅胶柱色谱、ODS 柱色谱、Sephadex LH-20 柱色谱 等多种色谱手段进行分离纯化，利用波谱学方法鉴定化合物的结构。结果 从吴茱萸 75%乙醇提取物中分离得到 8 个化合 物，分别鉴定为芥子醇 9-O-阿魏酰基-4-O-β-D-葡萄糖苷（1）、3-O-阿魏酰基奎尼酸甲酯（2 ）、咖啡酸（3 ）、阿魏酸（4 ）、 对羟基桂皮酸（5 ）、4- 甲氧基苯甲醇（6 ）、3, 4-二羟基苯甲酸（7 ）、7-羟基香豆素（8 ）。结论 化合物 1 为 1 个新的苯丙素 苷类化合物，命名为新吴茱萸苷。化合物 2 、3 、6、7 为首次从吴茱萸属植物中分离得到。 关键词：吴茱萸；苯丙素苷；新吴茱萸苷；3-O-阿魏酰基奎尼酸甲酯；咖啡酸；4- 甲氧基苯甲醇 中图分类号：R284.1 文献标志码：A 文章编号：0253 - 2670(2015)01 - 0015 - 04 DOI: 10.7501/j.issn.0253-2670.2015.01.004 A new phenylpropanoid glycoside from Euodia rutaecarpa ZHAO Nan, LI Zhan-lin, LI Da-hong, HUA Hui-ming Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China Abstract: Objective To study the chemical constituents from the 75% ethanol extract of Euodia rutaecarpa. Methods Chromatographic methods, such as silica gel, ODS, and Sephadex LH-20 column chromatography, were used for the isolation and purification. The structures were identified on the basis of spectroscopic analysis. Results Eight compounds were isolated from the 75% ethanol extract of E. rutaecarpa, and were identified as sinapyl alcohol 9-O-feruloyl-4-O-β-D-glucopyanoside (1), 3-O- caffeoylquinic acid methyl ester (2), caffeic acid (3), ferulic acid (4), p -hydroxycinnamic acid (5), 4-methoxybenzylalcohol (6), 3, 4-dihydroxy-benzoic acid (7), and 7-hydroxy coumarin (8). Conclusion Compound 1 is a new phenylpropanoid glycoside named neoeuodiside, and compounds 2, 3, 6, and 7 are isolated from the plants of Euodia J. R. et G. Forst. for the first time. Key words: Euodia rutaecarpa (Juss.) Benth; phenylpropanoid g