医学论文-肺表面活性物质预防早产儿呼吸窘迫综合征效果观察.docVIP

医学论文-肺表面活性物质预防早产儿呼吸窘迫综合征效果观察 【摘要】? 目的：探讨肺表面活性物质（PS）预防早产儿呼吸窘迫综合征（NRDS）的疗效。方法：我院出生的胎龄29～32周早产儿44例，随机分为预防组20例，治疗组24例，预防组于生后30 min内即从气管插管内分2次滴入PS 120 mg，用药后应用鼻塞持续气道正压（CPAP）辅助呼吸；治疗组确诊RDS后应用PS，方法同预防组。同时观察患儿呼吸、心率，并于用药6、24、48、72 h做血气分析。结果：预防组鼻塞CPAP辅助呼吸时间（26.4±13.6）h，鼻管法氧疗时间（39.6±16.1）h；治疗组分别为（96.0±19.6）h和（108.0±204.0）h。两组比较t 分别为9.47、8.6，P均＜0.05，预防组较治疗组明显缩短。48 h内各时段PaO2、PaCO2、pH预防组与治疗组比较差异均有统计学意义。结论：应用PS预防早产儿RDS，可减轻病情，避免机械通气、缩短氧疗时间、减少早期及后期并发症。 【关键词】? 早产儿；肺表面活性物质；呼吸窘迫综合征 ??? ［Abstract］ Objective:To investigate the effect of pulmonary surfactant (PS) in preventing premature infants from respiratory distress syndrome (NRDS). Methods:We divided 44 cases of premature infants of 29～32 week gestational age into two groups: 20 cases of the prevention group and 24 cases of the treatment group. Tracheal intubation was performed within 30 min in the prevention group, infusing PS and after the administration, the nasal continuous positive airway pressure ventilation was done. After RDS was final diagnosed in the treatment group PS? was applied, the same as the prevention group. At the same time the respiratory and heart rate were observed and at the time of 6, 24, 48, 72 hours after the application of the drug blood gas analysis were done.Results:In the prevention group, the time of nasal CPAP assisting breath was (26.4±13.6)h and the time of nasal oxygen therapy was (39.6±16.1)h, but in? the? treatment group, the time were (96.0±19.6)h and (108.0±204.0)h respectively. The difference of t=9.47 and t=8.6 (P0.05) in two groups was statistically significant, with that in the prevention group shortened. PaO2, PaCO2, pH in the prevention group compared with the treatment group were significantly different.Conclusions:PS prevention of RDS in premature infants can reduce illness, avoid mechanical ventilation, shorten oxygen therapy and reduce early and late complications. ??? ［Key words］ Premature infants; Pulmonary surfactant; Respiratory distress syndrome ??? 呼吸窘迫综合征（Respiratory distress sy