抗微生物药物（英文PPT）AntimicrobialMedicationsPPT.pptVIP

Distinguishing Antibiotics Antibiotics (as well as synthetic antimicrobials) differ in terms of… The organism they are or were isolated from. Their chemical structure. Their (chemo)Therapeutic index. Bacteriostasis versus bacteriostatic. Their spectrum of activity. Their pharmacokinetics (tissue distribution, metabolism, and excretion). Their site of action in bacterial cells. Interaction with other chemotherapeutics. Potential for evolution to resistance. Mechanism of toxicity to the host. Cost. Combination of Drugs For antibiotics “A” and “B” used in combination: Actual killing rate = A +