抗感染及抗感染药物（英文PPT）PPT.pptVIP

Cephalosporins Third Generation ceftriaxone (Rocephin) IV and IM, long half-life, once-a-day dosing Elimination is primarily hepatic Easily passes meninges and diffused into CSF to treat CNS infections ceftazidime (Fortaz, Tazidime) IV and IM forms Excellent gram-negative coverage Used for difficult-to-treat organisms such as Pseudomonas Eliminated renally instead of biliary route Excellent spectrum of coverage Cephalosporins Fourth Generation Newest cephalosporin drugs Broader spectrum of antibacterial activity than third generation, especially against gram-positive bacteria Tx: UT