抗生素PPT课件（英文精品） Metabolic engineering of bacteriaPPT.pptVIP

Metabolic engineering of bacteria;Many biological small molecules are useful;Increasing production of antibiotics (and other small molecules)--traditional methods;An alternative to simple random mutagenesis: genome shuffling;The shuffling advantage: simultaneous recombination of entire genomes (breeding) with multiple parents;Supplements required: pro, arg, ura (not cys) pro, cys, ura (not arg) arg, cys, ura (not pro) pro, arg, cys (not ura);;Test case: increase tylosin production by S. fradiae?;Comparing CSI to genome shuffling;Genome shuffling;Increasing production of a biological compou