Theoretical and Experimental Evaluation of PhasemDispersion Effects Caused by Brain Motion in Diffusion and Perfusion MR Imaging英文文献.pdfVIP

Original Research Theoretical and Experimental Evaluation of PhasemDispersion Effects Caused by Brain Motion in Diffusion and Perfusion MR Imaging Ronnie Wirestam, MSc Dan Greitz, MD, PhD Carsten Thomsen, MD Sara Brockstedt, MSc Magnus B. E.Olsson, PhD Freddy Stahlberg, PhD We investigated intravoxel phase dispersion caused by DURING recent years, several MR imaging methods have pulsatile brain motion in diffusion spin-echo pulse se- been proposed for the assessment of microscopic motion quences. Mathematical models were used to describe (ie,in vivo perfusion and diffusion).For example, gradient- the spatial and temporal velocity distributions of hu- sensitizing methods like intravoxel incoherent motion man brain motion. The spatial distributionof brain-tis- sue velocity introduces a phase spread over one voxel, (MM)imaging have received considerable attention (1-3). leading to signal loss. This signal loss was estimated The M M imaging methods have, however, also been sub- theoretically, and effects on observed diffusion coeffl- jected to numerous evaluations and discussions (M), cient and perfused capillary fraction were assessed. mainly in regard to the signal-to-noise ratio required for a When parameters from a diffusion pulse sequencewith- reliable estimation of the perfused capillary fraction and out motion compensation were used, and ECG trigger- the influence of macroscopic motion on the perfusion and ing with inappropriate delay times was assumed, the diffusion results. When using M M imaging methods for maximal signal loss caused by brain-motion-induced diffusion measurements, the quantif