MicroRNA Expression and Clinical Outcomes in Patients Treated with Adjuvant Chemotherapy after Complete Resection of Non–Small Cell Lung Carcinoma英文文献.pdfVIP
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Clinical Studies
Cancer
Research
MicroRNA Expression and Clinical Outcomes in Patients
Treated with Adjuvant Chemotherapy after Complete
Resection of Non–Small Cell Lung Carcinoma
1 2 3 2 2
Johannes Voortman , Akiteru Goto , Jean Mendiboure , Jane J. Sohn , Aaron J. Schetter ,
2 3 1 1 1 2
Motonobu Saito , Ariane Dunant , Trung C. Pham , Iacopo Petrini , Alan Lee , Mohammed A. Khan ,
Pierre Hainaut4 3 5 6 7
, Jean-Pierre Pignon , Elisabeth Brambilla , Helmut H. Popper , Martin Filipits ,
Curtis C. Harris2, and Giuseppe Giaccone1
Abstract
This study determined whether expression levels of a panel of biologically relevant microRNAs can be used
as prognostic or predictive biomarkers in patients who participated in the International Adjuvant Lung Cancer
Trial (IALT), the largest randomized study conducted to date of adjuvant chemotherapy in patients with rad-
ically resected non–small cell lung carcinoma (NSCLC). Expression of miR-21, miR-29b, miR-34a/b/c, miR-155,
and let-7a was determined by quantitative real-time PCR in formalin-fixed paraffin-embedded tumor speci-
mens from 639
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