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GP120: Target for
Neutralizing HIV-1
Antibodies
Ralph Pantophlet1 and Dennis R. Burton1,2
1Department of Immunology, 2 Department of Molecular Biology, The Scripps
Research Institute, La Jolla, California 92037; email: rpanto@,
burton@
Annu. Rev. Immunol. Key Words
2006. 24:739–69
AIDS, neutralizing antibodies, vaccine design, antigen engineering
First published online as a
Review in Advance on
Abstract
January 16, 2006
The Annual Review of The glycoprotein (gp) 120 subunit is an important part of the en-
Immunology is online at velope spikes that decorate the surface of HIV-1 and a major target
for neutralizing antibodies. However, immunization with recombi-
This article’s doi: nant gp120 does not elicit neutralizing antibodies against multiple
10.1146/annurev.immunol.24.021605.090557 HIV-1 isolates (broadly neutralizing antibodies), and gp120 failed
c to demonstrate vaccine efficacy in recent clinical trials. Ongoing
Copyright 2006 by
Annual Reviews. All rights crystallographic studies of gp120 molecules from HIV-1 and SIV
reserved
increasingly reveal how conserved regions, which are the targets of
073
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