Intestinal mucosal barrier function in health and disease英文文献.pdfVIP

R E V I E W S Intestinal mucosal barrier function in health and disease Jerrold R. Turner Abstract | Mucosal surfaces are lined by epithelial cells. These cells establish a barrier between sometimes hostile external environments and the internal milieu. However, mucosae are also responsible for nutrient absorption and waste secretion, which require a selectively permeable barrier. These functions place the mucosal epithelium at the centre of interactions between the mucosal immune system and luminal contents, including dietary antigens and microbial products. Recent advances have uncovered mechanisms by which the intestinal mucosal barrier is regulated in response to physiological and immunological stimuli. Here I discuss these discoveries along with evidence that this regulation shapes mucosal immune responses in the gut and, when dysfunctional, may contribute to disease. Mucosa-associated Complex multicellular organisms interface with their as size selectivity) varies with location in the intestine, lymphoid tissue external environments at multiple sites, including as permeability to larger solutes decreases from the 2 (MALT). The collections of mucosae of the airways, oral cavity, digestive tract and crypt to the