Patient Specific Computerized Phantoms to Estimate Dose in Pediatric CT英文文献.pdfVIP

Patient Specific Computerized Phantoms to Estimate Dose in Pediatric CT a b c d e f g W.P. Segars , G. Sturgeon , X. Li , L. Cheng , C. Ceritoglu , J.T. Ratnanather , M.I. Miller , B.M.W. h i j Tsui , D. Frush , and E. Samei a,c,i,jMedical Physics Graduate Program, a,b,c,jCarl E. Ravin Advanced Imaging Laboratories, a,b,c,i,j a,j j Dept. of Radiology, Dept. of Biomedical Engineering, Dept. of Physics, Duke University, Durham NC; bDept. of Biomedical Engineering, University of North Carolina, Chapel Hill NC; hRussell H. Morgan Dept. of Radiology, d,e,f,gCenter for Imaging Science, The Johns Hopkins University, Baltimore MD ABSTRACT We create a series of detailed computerized phantoms to estimate patient organ and effective dose in pediatric CT and investigate techniques for efficiently creating patient-specific phantoms based on imaging data. The initial anatomy of each phantom was previously developed based on manual segmentation of pediatric CT data. Each phantom was extended to include a more detailed anatomy based on morphing an existing adult phantom in our laboratory to match the framework (based on segmentation) defined for the target pediatric model. By morphing a template anatomy to match the patient data in the LDDMM framework, it