Direct interaction between NHERF1 and Frizzled regulates b catenin signaling英文文献.pdfVIP

Oncogene (2010), 1–11 2010 Macmillan Publishers Limited All rights reserved 0950-9232/10 /onc ORIGINAL ARTICLE Direct interaction between NHERF1 and Frizzled regulates b-catenin signaling , , , , , 1 2 1 1 2 3 4 1 3 1 4 DS Wheeler , SR Barrick , MJ Grubisha , AM Brufsky , PA Friedman and G Romero 1Laboratory for GPCR Biology, Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; 2Medical Scientist Training Program, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; 3Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA and 4 University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA Although Wnt-Frizzled (Fzd) signaling is critical in the The Na þ /H þ exchange regulatory factor 1 (NHERF1, pathophysiology of carcinomas, its role in human breast also known as the Ezrin-binding phosphoprotein of cancer has been difficult to establish. We show here that 50 kDa, EBP50) is a cytosolic PSD-95/Drosophila discs the adaptor protein Na þ /H þ exchange regulatory factor1 large/ZO-1 (PDZ) adaptor protein abundantly expressed (NHERF1), a protein abundantly expressed in normal in human mammary epithelium. NHERF1 was initially mammary epithelium, regulates Wnt signaling, maintaining identified as a regulator of the localization, signa