High Field MR Microscopy Using Fast Spin Echoes英文文献.pdfVIP

High-Field MR Microscopy Using Fast Spin-Echoes Xiaohong Zhou, Gary P. Cofer, Steve A. Suddarth, G. Allan Johnson Fast spin-echo imaging has been investigated with attention 3D experiments with large cubic arrays (e.g., 2563). The to the requirements and opportunities for high-field MR mi- reduced time to traverse k-space also allows a longer TR croscopy. Two- and three-dimensional versions were imple- to be used in Tz-weighted images. The capability of pro- mented at 2.0 T, 7.1 T, and 9.4 T. At these fields, at least eight ducing T,-weighted images is particularly important in echoes were collectable with a 10 ms TE from fixed tissue high-field MRM since much tissue contrast arises from specimens and living animals, giving an eightfold improve- apparent Tz variations. ment in imaging efficiency.To reduce the phase-encodinggra- dient amplitude and its duty cycle, a modified pulse sequence FSE is more suitable for high-field MR microscopy with phase accumulationwas developed. Images obtained us- than other fast imaging techniques based on gradient ech- ingthis pulse sequence exhibited comparable signal-to-noise oes (8-10). At high fields (Bo 1.5 T), magnetic suscep- (SNR) to those obtained from the conventional fast spinecho tibility differences, both macroscopic and microscopic, pulse sequences. Signal losses due to imperfections in RF cause severe distortion in local magnetic fields and a pulses and lack of phase rewinders were offset in this se- significant reduction in Tz*(11,121.RF refocused echoes quence by reduced diffusion losses incurred with the gradi- used in FSE minimize these