Positional flexibilities of amino acid residues in globular proteins英文文献.pdfVIP

In!. J. Peptide Protein Res. 32, 1988, 241-255 Positional flexibilities of amino acid residues in globular proteins R. BHASKARAN and P.K. PONNUSWAMY Department of Physics, Bharathidasan University, Tiruchirapalli, India Received 7 May 1987,accepted for publication 8 March 1988 The fluctuational amplitudes of the amino acid residues in 19protein molecules are computed by the use of our differential equation model and are analysed statistically to get new information as to their stability,position dependent nature, distribution and group dynamical behaviour, etc. The symmetric/asymmetric distribution of amino acid residues in the protein molecules is described by introducing a parameter called the “flexibility index” for each of the residue types. Finally, the overall flexible nature of the amino acid residues with respect to their spatialpositioning is explained and their relationships with the residue properties are derived. Key words: differential equation model; flexibility index; fluctuational amplitudes; spatial posi- tions; symmetric/asymmetric distribution The specificity of the protein molecules to The physical, chemical, conformational, and perform their respective functions lies in the energetic properties of the amino acid re- distribution and positioning of their amino sidues have been considered extensively in acid residues. In spite of the general observa- order to account for the deviational charac- tion that nonpolar residues are buried and ters of the residues (2). The spatial distribu- polar residues are exposed, the required speci-