原创力文档Foxa1 Functions as a Pioneer Transcription Factor at Transposable Elements to Activate Afp during Differentiation of Embryonic Stem Cells英文文献.pdfVIP
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Supplemental Material can be found at:
/content/suppl/2010/03/26/M109.088096.DC1.html
THE JOURNAL OF BIOLOGICAL CHEMISTRY VOL. 285, NO. 21, pp. 16135–16144, May 21, 2010
Printed in the U.S.A.
Foxa1 Functions as a Pioneer Transcription Factor at
Transposable Elements to Activate Afp during Differentiation
□
of Embryonic Stem Cells* S
Received for publication, November 23, 2009, and in revised form, March 25, 2010 Published, JBC Papers in Press, March 26, 2010, DOI 10.1074/jbc.M109.088096
‡1 ‡ § ¶2 ‡3
Joseph H. Taube , Kendra Allton , Stephen A. Duncan , Lanlan Shen , and Michelle Craig Barton
From the ‡Department of Biochemistry and Molecular Biology, Program in Genes and Development, Graduate School of
Biomedical Sciences, Center for Stem Cell and Developmental Biology, University of Texas M.D. Anderson Cancer Center, Houston,
Texas 77030, the ¶Department of Pediatrics, Baylor College of Medicine, USDA Children’s Nutrition Research Center, Houston,
Texas 77030, and the §Department of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin,
Milwaukee, Wisconsin 53226
Epigenetic control of genes that are silent in embryonic stem erty of self-renewal demands strict maintenance of heritable
cells, but destined for expression during differentiation, patterns of expression, whereas pluripotency implies plasticity
includes distinctive hallmarks, such as simultaneous activating/ and tolerance of
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