Laser induced thermal response and characterization of nanoparticles for cancer treatment using magnetic resonance thermal imaging英文文献.pdfVIP

Laser-induced thermal response and characterization of nanoparticles for cancer treatment using magnetic resonance thermal imaging Andrew M. Elliott and R. Jason Stafforda Department of Imaging Physics, The University of Texas, M. D. Anderson Cancer Center, Houston, Texas 77030 Jon Schwartz and James Wang Nanospectra Biosciences, Incorporated, EI Rio Street, Suite 150, Houston, Texas 77054 Anil M. Shetty Department of Imaging Physics, The University of Texas, M. D. Anderson Cancer Center, Houston, Texas 77030 Chirs Bourgoyne Nanospectra Biosciences, Incorporated, EI Rio Street, Suite 150, Houston, Texas 77054 Patrick O’Neal Institute for Manufacturing, Louisiana Tech University, 911 Hergot Avenue, P. O. Box 10137, Ruston, Louisiana 71270 John D. Hazle Department of Imaging Physics, The University of Texas, M. D. Anderson Cancer Center, Houston, Texas 77030 Received 30 January 2007; revised 21 March 2007; accepted for publication 28 March 2007; published 27 June 2007 Spherical nanoparticles with a gold outer shell and silica core can be tuned to absorb near-infrared light of a specific wavelength. These nanoparticles have the potential to enhance the treatment efficacy of laser-induced thermal therapy LITT. In order to enhance both the potential efficacy and safety of such procedures, accurate methods of treatment planning are needed to predict the temperature distribution associated with treatment application. In this work, the standard diffusion approximation was used to model the laser fluence in phantoms containing different concentrations of nanoparticles, and the temperature distribution within the phantom was simulated in three- d