Oxidative stress, inflammation, and cancer How are they linked英文文献.pdfVIP

Free Radical Biology Medicine 49 (2010) 1603–1616 Contents lists available at ScienceDirect Free Radical Biology Medicine journal homepage: www. elsevier.c om/l oc ate/ freeradbiomed Review Article Oxidative stress, inflammation, and cancer: How are they linked? Simone Reuter, Subash C. Gupta, Madan M. Chaturvedi, Bharat B. Aggarwal ⁎ Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA a r t i c l e i n f o a b s t r a c t Article history: Extensive research during the past 2 decades has revealed the mechanism by which continued oxidative Received 25 June 2010 stress can lead to chronic inflammation, which in turn could mediate most chronic diseases including cancer, Revised 30 August 2010 diabetes, and cardiovascular, neurological, and pulmonary diseases. Oxidative stress can activate a variety of Accepted 3 September 2010 transcription factors including NF-κB, AP-1, p53, HIF-1α, PPAR-γ, β-catenin/Wnt, and Nrf2. Activation of these Available online 16 September 2010 transcription factors can lead to the expression of over 500 different genes, including those for growth factors, inflammatory cytokines, chemokines, cell cycle regulatory molecules, and anti-inflammatory molecules