AntidiabeticDrugsInsulinAndOralAntisiabeticDrugs分析课件.pptVIP

Antidiabetis Drugs－Insulin  and Oral Antisiabetis Drugs Overview diabetes mellitus A chronic condition associated with abnormally high blood sugar. Results from either deficiency of or a resistance to insulin- a hormone produced by the pancreas whose function is to lower blood sugar. Overview morbidity： 300,000 people－→0.67％ 40 years old―→2.53％ 1994 25~64 years old－→2.51％ 1996 20~75 years old－→3.21％ 1997―→13,500,000 people (all over the word) Prediction:2025―→30,000,000 people Overview Cause by many of reasons ――chronic hyperglycemia－→metabolic disorder Hyperglycemia ―― a group of diseases characterized by high levels of blood glucose resulting from defects in insulin production, insulin action, or both. Insulin: B cells ――synthesis－→secretion ――blood circulation－→target cells－→binding with insulin receptor －→intracellular substance metabolism any link going wrong －→diabetes mellitus Overview Diabetes Mellitus ――long-term disease ――multisystem damage－→functional defect and failure Severe－→diabetic ketoacidosis－→coma Etiopathogenisis ――heredity, autoimmunity, environmental factor Diagnosis：urine glucose, blood glucose Overview Therapy: early treatment, long term therapy, combined therapy and therapeutic measure individualization Purpose：blood glucose－→normal, to correct metabolic disorder, increase in life span, decrease death Principle：persevere (cannot cure) Overview Drink and food：gross calorific value Kg＝height－105 Daily Kg＝105～125.5K （25～30Kcal） (25～40Kcal) Therapy：before meals Substance Metabolic Disorder and Clinical Situation of Diabetic glucose utilization disorder→glucose decomposition decrease→energy insufficient→starvation condition →polyphagia hyperglycemia →glucosuria →hypertonicity diuresis →polyuria protein degradation accentuation┤ ↓ athrepsy dehydration thirst→polydipsia ↓ lipolysis excessive