USMLE题库Hepatic1-10-4-6.pptxVIP

Hepatic题库Q 1 Autopsy of a 21-yaer-old Caucasian shows extensive atrophy of basal ganglia and increased brain copper content. The main mechanism of excess copper removal in the healthy human body is:A.Glomerular filtration B.Renal tubular secretion C.Hepatic excretion into bile D.Intestinal epithelial accumulation E.Colonic active secretionA 1: Correct answer: CWilsons disease is an autosomal recessive disorder characterized by toxic accumulation of copper within organ tissues (especially the liver, brain, and eye).Normally, approximately 60% of ingested copper (0.6-3.0 mg/day) is absorbed in t