[临床医学]内分泌总论.ppt

Radioiodide (I-123) uptake of the thyroid gland showing a toxic adenoma longitudinal and transverse images of the thyroid Treatment of the Endocrine Disease Prevention Treatment for the cause Treatment for the dysfunction Treatment for the abnormal metabolism Treatment of the Endocrine Disease Hormone deficiency—replacement in physiologic setting Hormone excess state---pharmacologic radiotherapy surgical techniques Goals To know the endocrine system To understand the pathophysiologic processes that underlie hormonal dysfunction and endocrine neoplasia To develop the ability to solve clinical problems in endocrinology and metabolism To have fun while achieving the first three goals * topic * Growth and Development Reproduction Energy metabolism (intake, production, utilization and storage of energy) Maintenance of the internal environment (regulation of blood volume, electrolytes, body temperature, calcium homeostasis etc.) Multiple effects on other organs (skeleton, heart, * * Corpus luteum * Tetraiodothyronine 磷phosphorus * Glomerulosa fasciculatae reticular * entrain * Endocrine system (information is carrentied by chemical mediators) Nervous system (information is carried by neural impulses) Immune system * * The target cells through the circulation (most hormones). The same tissue without entering the circulation (sex steroids in the ovary, angiotensin II in the kidney) The same cell (autocrine action)- cancer cells * Solinocrine腔分泌 Amphicrine双重分泌 * 前列腺素prostaglandin * Translation mRNA into protein precursor ? Posttranslational: – cleavage (pre-pro-hormone, prohormone, hormone) – processing (thyroglobulin, thyroid hormones) ? Submits: – derived from single precursor – derived from separate precursors ? The same peptide can be formed from different prohormone encoded by distinct genes (TSH) ? Individual prohormone can be metabolized into different hormon