最新 Hematopoietic and Lymphoid Systems.pptVIP

Thrombotic Thrombocytopenic Purpura and Hemolytic Uremic Syndrome Pentad of TTP: Fever, ↓ PLTs, microangiopathic hemolysis, CNS and renal Sx D/D Hemolytic uremic syndrome Renal CNS, childhood onset, follows E. coli O157:H7 infection that produces Shiga-like toxin that damages endothelial cells Common finding: fibrin microthrombi in the microcirculation resulting in microangiopathic hemolysis (schistocytes) TTP: deficiency of vWF cleaving protease Familial/genetic Autoantibody Treatment: Therapeutic plasma exchange + Immunosuppressants Heparin Induced Thrombocytopenia with Thromboses (HITT