Traditional Posters Neuroimaging - ISMRM传统的神经影像的今年的海报.doc

Traditional Posters: Neuroimaging Imaging of Dementia Neurodegeneration Hall B Tuesday 13:30-15:30 1938. Degeneration of Subcortical White Matter in Alzheimers Disease: Atlas-Based Automated Mapping and Its Diagnostic Utility Based on Multi-Variate Model Takashi Yoshiura1, Akio Hiwatashi1, Koji Yamashita1, Hironori Kamano1, Yukihisa Takayama1, Eiki Nagao1, Tuvshinjargal Dashjamts1, Hiroshi Honda1 1Department of Clinical Radiology, Kyushu University, Fukuoka, Japan We measured mean diffusivities (MD) in subcortical white matter (WM) in 78 different cortical regions using an atlas-based mapping method in 33 patients with Alzheimer?fs disease (AD) and 28 healthy control subjects to determine whether the topographical pattern of the diffusion abnormalities can be used to diagnose AD. Uni-variate analysis in which discrimination was attempted based on MD in the single region resulted in the accuracy of 88.5 %. Multi-variate analysis in which a linear discriminant function based on MDs from multiple cortical regions increased the accuracy up to 96.7 %. 1939. Deterioration of Abstract Reasoning Ability in MCI and Alzheimers Disease: Correlation with Local Gray Matter Volume Loss Using DARTEL VBM Analysis Takashi Yoshiura1, Akio Hiwatashi1, Koji Yamashita1, Hironori Kamano1, Yukihisa Takayama1, Eiki Nagao1, Tuvshinjargal Dashjamts1, Hiroshi Honda1 1Department of Clinical Radiology, Kyushu University, Fukuoka, Japan We estimated brain regions whose damages are responsible for the deterioration in abstract reasoning ability measured by Raven?fs colored progressive matrices (CPM) in 37 patients with Alzheimer?fs disease (AD) (n=19) and mild cognitive impairment (MCI) (n=18) using VBM with non-linear registration based on DARTEL algorithm. A multiple regression analysis was used to map the regions where gray matter volumes were correlated with CPM scores. Significant correlations were seen in 14 regions with the strongest correlation in the left middle frontal gyrus. Resul