毕业设计（论文）-补肾益精法治疗肾精不足型高血压病(2级）的临床研究精选.docxVIP

提要目的：观察左归丸对肾精不足型高血压(Ⅱ期）的临床疗效，探讨本方的作用机制，评价其疗效安全性。拟为临床治疗高血压提供实际有价值的治疗途径。方法：按照纳入和排除标准选取山东中医药大学第一附属医院心内科门诊及综合内科住院病例60例，随机分为试验组和对照组各30例。两组患者的一般情况无统计学差异。对照组运用西药氯沙坦治疗，试验组在治疗氯沙坦基础上加中药汤剂左归丸，一日一剂，早晚餐后半小时温服。4周后进行临床疗效评定。分别于治疗前、后行一般检查项目：脉搏、呼吸、血压、心率、肝功、肾功、心电图等检查，观察两组患者治疗前后的动态血压疗效评定、症状严重程度、中医症状总积分、中医总疗效、单项症状疗效判定,从而评价疗效及安全性。结果：经研究发现，左归丸可以明显降低患者血压水平，对比两组临床疗效，治疗组对照组无显著降压差异；中医症状严重程度对照，试验组优于对照组（P＜0.05）；两组患者中医单项症状疗效对比，试验组优于对照组（P＜0.05）；中医症状总积分对比，试验组优于对照组（P＜0.05）；中医总疗效对比，试验组优于对照组(P＜0.05)。总体比较，试验组疗效优于对照组。在肝肾功能安全性指标方面治疗前后无明显变化（P＞0.05），应用安全。结论：左归丸具有良好的降压效果，可以缓解患者的临床症状，临床作用安全可靠。关键词：高血压病；补肾益精；左归丸；临床观察；中医。Clinical Research of? the treatment of deficiency of nephorjing type2 hypertension with zuogui-wan decoctioonSpeciality:Cardiovascular disease of Internal Medicine of TCMAuthor:liu JimingTutor:Meng ZhaoyangAbstract Object:linical Observation Zuogui-wan to kidney essence deficiency hypertension (Ⅱ period), and to explore the mechanism of the party, to evaluate its efficacy and safety. It intends to provide the actual valuable therapeutic approach for the clinical treatment of hypertension Methods:Selected in accordance with inclusion and exclusion criteria of Shandong University of Traditional Chinese Medicine First Affiliated Hospital of outpatient and inpatient comprehensive medical cases, 60 cases were randomly divided into experimental group and control group 30 cases. Generally the two groups were not statistically different. Use of western medicine control group treated with losartan, the experimental group and traditional Chinese medicine decoction Zuogui-wan losartan in treatment based on day one, sooner or later, half an hour after a meal, warm clothes. Clinical assessment of efficacy after 4 weeks. Before treatment, underwent a general examination items: pulse, respiration, blood pressure, heart rate, liver function, renal function, electrocardiogram and other tests, ambulatory blood pressure effect was observed before and after the two groups of patients assessed the severity of symp