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Drugs of the Future 2009, 34(5): 405-417
Copyright © 2009 Prous Science, S.A.U. or its licensors. All rights reserved.
CCC: 0377-8282/2009
DOI: 10.1358/dof.2009.34.5.1364290
TARGETS TO WATCH
THERAPEUTIC TARGETS FOR MULTIPLE SCLEROSIS
L.A. Sorbera, C. Dulsat, E. Rosa
Prous Science, Provenza 388, 08025 Barcelona, Spain
CONTENTS population is approximately 1 in 1,000. The European total mean MS
incidence rate has been estimated to be 4.2 cases per 100,000/year,
Abstract . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .405
whereas a much lower prevalence has been reported in Asia (1-5 per
Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .405 100,000) (3, 4).
Targets . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .406
There are several subclasses of MS. Relapsing–remitting MS
References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .415
(RRMS) is the most frequent form at first diagnosis and is character-
ized by unpredictable relapses or attacks, during which new symp-
toms appear or exis
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