[医学]3 membrane molecules of immune cells.pptVIP

* 3 Membrane Molecules of Immune Cells Master the definitions and functions of leukocyte differentiation antigen, CD and adhesion molecules; Master the surface markers on the T and B cells; Master the structures and functions of TCR and BCR.. 3-1 General Features of Membrane Molecules of Immune Cells Lymphoid progenitor B lymphocyte T lymphocyte Natural killer (NK) cell CD4/CD8, CD3 CD19,20 CD34 CD56 Surface markers for cell differentiation, maturation and activation CD (Cluster of Differentiation) Leukocyte Differentiation Antigens, LAD Leukocyte Differentiation Antigens, LAD Leukocyte differentiation antigens are cell surface molecules which may appear or disappear from cell membrane when stem cell differentiate into different lineage cells or when blood cells are in maturational stages and activation status. Expressed on: Leukocyte Blood cell Non-hematopoietic cells Signals transduction by membrane molecules ITAM (immunoreceptor tyrosine-based activation motifs) is present in the activated receptors of immune cells. (BCR/Ig?, Ig?, TCR/CD3, Fc?R and Fc?R) ITIM (immunoreceptor tyrosine-based inhibitory motifs) is present in the inhibitory receptors of immune cells. (Fc?RIIIB-1, CD22 CTLA-4) Cluster of Differentiation, CD Cell surface molecules can be recognized by particular monoclonal antibodies. All of the monoclonal antibodies that react with a particular membrane molecule are grouped together as a cluster of differentiation (CD). CD molecules on the surface of T cell Antigenic peptide Target cell T cell Self-renewing stem cell Puripotent stem cell Myeloid progenitor Lymphoid progenitor B lymphocyte T lymphocyte Natural killer (NK) cell Erythroid CPU Megakarycyte Basophil CPU Eosinophil CPU Granulocyte-monocyte CPU Eosinophils Basophils monocyte Erythrocytes Platelets Neutrophils CD34 CD4/CD8 CD19 3-2 Adhesion Molecules The molecules that mediate contact and binding between cells or between cells and extracellular matr