中药接骨丸促进肾虚骨折愈合的生物化学研究-中国骨伤.PDFVIP

# 658 # 2000 11 13 11 China J Orthop T rauma, November 2000, Vol. 13, No. 11 冯坤 刘月桂 郭建刚 毛书歌 陈宝龙 ( , 471002) 24 07cm ,, , , 36 , , , ( P 005) , ( P 005) A biochemical study of the effect of! JIEGUWAN∀ on improving fracturehealing of rabbits with SHEN U FENG Kun, LI U Yuegui, GUO Jiangang, et al. Luoyang Orthop aedics and Trau atological Institute of Henan(Henan Luoyang,471002) Abstract Objective To study the therapeutic effect of ! JIE UWAN∀( J W)( herb pills for enhanc ing fracture healing) on fracture healing in animal models with SHENXU ( kidney deficiency) .Methods The bilateral midshaft defects of 7mm were made in the radii of 24 rabbits, which were then divided into three groups. 1.The J W group and 2.T he control group in both of them prednisonewas used to produce SHENX U,and 3. The blank group was raised with routine feeding without receiving prednisone. J W group were treated with J W and other two groups (the control and the blank) had the same fracture and received no J W.The animals were sacrificed at 3rd and 6th weeks for blood and callus analysis.Results The indices of callus repair in control group were lower than that of blank and J W group, the plasm ALP and BMC, BMD, Ca and P of callus in J W group were markly higher than that of control group ( P 0.05) .The blood viscos ity of J W group was significantly lower than that of control group. Conclusion Fracture healing was inhibit ed by prednisone.J W antagonized this inhibition and improved the process of fracture healing. Key Words Fracture healing Drugs,Chinese herbal Kidney deficiency , , , , , 1.2 , 13 , , , 9g , 1 , 971027