Long acting bronchodilators improve Health Related Quality of…长效支气管扩张药提高的健康相关质量.pdfVIP

Respiratory Medicine (2013) 107, 1465e1480 Available online at ScienceDirect journal homepage: /locate/rmed REVIEW Long-acting bronchodilators improve Health Related Quality of Life in patients with COPD Fulvio Braido a,*,1, Ilaria Baiardini a,1, Mario Cazzola b, Guy Brusselle c, Fiorenza Marugo a, Giorgio Walter Canonica a a Allergy Respiratory Diseases Clinic e DIMI e University of Genoa, IRCCS AOU San Martino-IST, Genova, Italy b Unit of Respiratory Clinical Pharmacology, Department of System Medicine, University of Rome ‘Tor Vergata’ Rome, Italy c Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium Received 8 February 2013; accepted 8 August 2013 Available online 31 August 2013 KEYWORDS Summary Long-acting Background: Long-acting bronchodilators are first-line treatment for chronic obstructive pul- bronchodilators; monary disease (COPD), and their efficacy on lung function and clinical parameters is recog- COPD; nized. Quality of life; Objective: To explore the available evidence about the effects of long acting bronchodilators Health status on Health Related Quality of Life (HRQoL) and Health Status (HS) in clinical research. Methods: Randomized controlled trials published till December 2012 evaluating HRQoL/HS in COPD by means of validated questionnaires were analysed. Results: Fifty-one trials on Long acting b2 agonist (LABA) and Long acting Anticholinergic (LAMA) met the inclusion criteria. A total of 37,225 moderate-severe COPD patients testing