Targeted Deletion of Somatotroph Insulin Like Growth Factor I…靶向删除生长激素胰岛素样生长因子.pdfVIP

O R I G I N A L R E S E A R C H Targeted Deletion of Somatotroph Insulin-Like Growth Factor-I Signaling in a Cell-Specific Knockout Mouse Model Christopher J. Romero, Yewade Ng, Raul M. Luque, Rhonda D. Kineman, Linda Koch, Jens C. Bruning, and Sally Radovick Division of Pediatric Endocrinology (C.J.R., Y.N., S.R.), Johns Hopkins University School of Medicine, Baltimore, Maryland 21208; Department of Cell Biology, Physiology, and Immunology (R.M.L.), University of Co´ rdoba, 14014 Co´ rdoba, Spain; Section of Endocrinology, Diabetes, and Metabolism (R.D.K.), Department of Medicine, University of Illinois at Chicago and Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois 60612; and Department of Mouse Genetics and Metabolism (L.K., J.C.B.), Institute for Genetics, University of Cologne and Center of Molecular Medicine Cologne, Cologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases, D-50674 Cologne, Germany, and Max Planck Institute for the Biology of Ageing and Second Department for Internal Medicine, University Hospital Cologne, D-50931 Cologne, Germany The role of IGF-I in the negative regulation of GH expression and release is demonstrated by in vitro and in vivo models; ho