The BRC repeats in BRCA are critical for RAD binding and…在中的重复对绑定至关重要，.pdfVIP

Proc. Natl. Acad. Sci. USA Vol. 95, pp. 5287–5292, April 1998 Medical Sciences The BRC repeats in BRCA2 are critical for RAD51 binding and resistance to methyl methanesulfonate treatment (breast cancerDNA repair) PHANG-LANG CHEN *, CHI-FEN CHEN *, YUMAY CHEN, JUN XIAO, Z. DAVE SHARP, AND WEN-HWA LEE† Department of Molecular Medicine and Institute of Biotechnology, University of Texas Health Science Center, San Antonio, TX 78245 Edited by Charles M. Radding, Yale University School of Medicine, New Haven, CT, and approved February 26, 1998 (received for review November 10, 19