代谢组学在肿瘤研究中的应用精品.ppt

2-1 p53 in tumor cell metabolism: oxidative phosphorylation p53 Cell 126, July 14, 2006 One target of p53 known to affect glucose oxidative phosphorylation is SCO2 2-1 p53 in tumor cell metabolism: oxidative phosphorylation One target of p53 known to affect glucose oxidative phosphorylation is SCO2 2-1 p53 in tumor cell metabolism: pentose phosphate pathway Figure 1 The three metabolic fates of glucose in cells and the role for p53 in glucose metabolism nature cell biology VOLUME 13 | NUMBER 3 | MARCH 2011 2-1 p53 in tumor cell metabolism: pentose phosphate pathway 2-1 p53 in tumor cell metabolism: pentose phosphate pathway Figure 1 . p53 deciency correlates with increases in PPP flux, glucose consumption and lactate production 2-1 p53 in tumor cell metabolism: pentose phosphate pathway Figure 2. p53 regulates NADPH levels, lipid accumulation and G6PD activity 2-1 p53 in tumor cell metabolism: pentose phosphate pathway Figure 3 p53 interacts with G6PD and inhibits its activity independently of transcription. 2-1 p53 in tumor cell metabolism: pentose phosphate pathway Figure 4 p53 inhibits the formation of dimeric G6PD holoenzyme. p53 regulation of energy metabolism 2-1 p53 in tumor cell metabolism 2-1 p53 in tumor cell metabolism: glutamine metabolism Biochemistry of glutamine metabolism (main pathways): glutaminase 2-1 p53 in tumor cell metabolism: glutamine metabolism 2-1 p53 in tumor cell metabolism: glutamine metabolism Model for regulation of intracellular ROS levels by GLS2. 2. 2 HIF-1 与肿瘤代谢 2-2 HIF-1 in tumor cell metabolism HIF-1: upstream and downstream of cancer metabolism. Curr Opin Genet Dev. 2010 Feb;20(1):51-6. 2-2 HIF-1 in tumor cell metabolism HIF-1: activating transcription of genes encoding glucose transporters and glycolytic enzyme Expression of genes encoding glucose transporters and glycolytic enzymes. The glycolytic pathway is shown at left. Symbols for genes encoding the re