细菌性疾病的新疗法——噬菌体疗法-山东宝来利来生物工程股份有限.PDFVIP

第28卷第7期 生命科学 Vol. 28, No. 7 2016年7月 Chinese Bulletin of Life Sciences Jun., 2016 DOI: 10.13376/j.cbls/20160 文章编号：1004-0374(2016)07-0000-00 细菌性疾病的新疗法——噬菌体疗法 郭婷婷，李　玲*，孙元章，陈玉春，谷　巍 ( 271000) 山东宝来利来生物工程股份有限公司生物研究院，泰安 摘　要 ：在败血症等一些严重细菌性疾病的防治上，传统的抗生素法出现了越来越严重的细菌耐药性、残 留等问题，因此，噬菌体疗法等一些非抗疗法日渐受到人们的广泛关注。现从噬菌体分类及生物学特征， 国内外利用噬菌体防治动物和人类细菌感染疾病的临床试验结果进行了阐述和评价，并分析了噬菌体疗法 的优缺点。噬菌体疗法表现出许多抗生素法无法比拟的优势，是一种非常有发展前景的替代抗生素治疗新 方法。 关键词：细菌感染；多重耐药菌；抗生素法；噬菌体治疗 中图分类号：Q819　　文献标志码：A The new therapy of bacteria infection— bacteriophage therapy GUO Ting-Ting, LI Ling*, SUN Yuan-Zhang ,CHEN Yu-Chun, GU Wei (Biological Research Institute, Shandong Baolai-Leelai Bio-engineering Co., Ltd, Tai’an71000, China) Abstract: In the prevention of sepsis and some other severe bacterial diseases, the traditional antibiotic therapy appeared more and more serious bacterial resistance, antibiotic residues and other problems, therefore phage therapy and some other non-anti therapies have received widespread attention. Here we elucidate and evaluate the classification and biological characteristics of phages, the clinical results of the application of phage in the treatment of animal and human bacterial infections, and also analyze the advantages and disadvantages of phage therapy. Phage therapy has shown many incomparable advantages, which is a promising alternative to antibiotics for bacterial pathogens. Key words: bacterial infection; multiple resistant bacteria; antibiotics; bacteriophage therapy 2011 年，Sulakvelidze [1] Bacteriophage 疗效不一[2,4] 20 在 杂志 ，该法开始受到争议，且随着