[药学]遗传药理学总论-周宏灏院士.pptVIP

PHARMACOGENETICS – the study of the role of inheritance in inter-individual variation in drug response PHARMACOGENOMICS – the use of DNA sequence information to measure and predict the reactions of individuals to drugs Often, these terms are used interchangeably Paradox of Modern Drug Development Variation in human genomics 90% of human inherited variability is produced by SNP There are 1 SNP in 100 - 300 base pairs in the over three billion DNA base pairs The SNP are in both coded and nocoded area in genome Ususlly not affect to cellular function but Disease susceptibility and drug effect CY