小分子RNA与心血管疾病精选.pptVIP

MicroRNAs in Vascular Disease the beginning of a new tale Chunxiang Zhang M.D., Ph.D. University of Medicine and Dentistry of New Jersey MiroRNAs MicroRNAs (miRNAs) are a novel class of endogenous, small, noncoding RNAs that regulate gene expression. Mature miRNAs are 18- to 24-nucleotide(nt)-long. They negatively regulate protein expression of their target mRNAs by either translation inhibition or degradation. As a group, miRNAs are estimated to regulate at least 30% of the human genes. Pathway of Genetic Information Flow and RNA “revolution” 1.The standard pathway of information