严重创伤后应激反应的调控机理.PDFVIP

Chinese Journal of Pathophysiology 2001, 17( 1) : 89- 92 ∀ 89 ∀ [ ] 1000- 4718(2001)01- 0089- 04 刘都户, 粟永萍, 程天民 ( , 400038) Molecular biological responses to severe posttraumatic stress LIU Du- hu, SU Yong- ping, CHEN Tian- min ( Institute of Combined Inj ury , Third M ilitary Med ical University , Chongqing 400038, China) [ A Review] Traumatic stress in thenormal individual results in activation of the sympatho- adrenal system caus ing a rise in noradrenaline and adrenaline, acutephaseresponse in liver ,and activation of thehypothalamic- pituitary- adrenocortical(HPA) system resulting in elevated levels of cortisol. Studies in animals and in humans with posttraumatic stress disorder indicate that successful adaptation to stress is a prerequisite for the survival of all organisms living in an enviroment in which noxious stimuli are constantly present. [] ,; - ; ; [MeSH] Stress disorders, post- traumatic; Hypothalamo- hypophyseal system; Sympathetic nervous system; Transcription factors + [] R363.2 2 [] A (permissive function) ,, [, , , - - ( hy C , C pothalamic- pitutitary- adrenal axis,HPA ) , , C (acute phase response, APR) , ] , , HPA APR 3: HPA 3 : () , ; ; ! , , HPA ; ,: 11 Eskp , , C HPA ; ann , HPA , , C ACTH [1, 2] , , 12 1 HPA , 1/ 10110 C, (glucocorticoid, C) , C : , , [ ] 2000- 04- 14 [ ] 2000- 07- 25 , ∀ 90 ∀ ( proopiomelanocortin,POMC) - - 6TNF, [ 3- 5] ,IL- 6 IL- 1TNF 13 , , C , , ,